Goals

  • We would like to establish a state-of-the-art Pre-clinical research center in India to offer research training and undertake collaborative cardio metabolic research work in India and abroad.
  • C3RF will serve as a training centre for graduate students and postdoctoral fellows to undertake their research in Cardio Metabolic Diseases.
  • C3RF will get both intra and extra mural grant supports to undertake research.
  • C3RF will publish the research work in highly reputed journals under the name of the affiliated research institute.

Current Focus

  • Major focus of our research is in cardiac hypertrophy, cardiac failure and myocardial infarction.
  • Research objectives are focused to determine the mechanical and biochemical changes at molecular and cellular levels responsible for the adaptive and maladaptive processes of cardiac hypertrophy.

Research Programme

C3RF is working on the following models of cardiac disease in small animals (primarily in mouse).

  • Pressure-overload hypertrophy
  • Myocardial infarct model
  • Left ventricular ischemia and reperfusion models
  • Isolate both cardiomyocytes and cardiac fibroblasts to perform in vitro experiments
  • Process issue and cell culture sample for biochemical and histochemical analyses

All these animal models will be validated scientifically using a well-established noninvasive small animal echocardiography for assessing systolic and diastolic and valvular function of the diseased heart.

 

MENTOR-ADVISOR PRE CLINICAL RESEARCH WING

 


Dr. Dhandapani Kuppuswamy, Ph.D.

Associate Professor of Medicine/Cardiology
Medical University of South Carolina
Charleston, USA.

HE IS HAPPY TO OVERSEE THE NEWLY FORMED RESEARCH CENTRE IN INDIA

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  • Masters & Doctoral degrees at the University of Madras, India
    1984 – Moved to USA as a postdoctoral fellow.
  • Research Associate at Washington University, St. Louis from 1986-1993.
    1994 – Joined MUSC as a faculty.
  • Primary interest in the field of cardiac hypertrophy and signal transduction
    Contributed to the field of cardiac hypertrophy – 20 years.
  • At MUSC most of his work is devoted to cardiac hypertrophy. His lab showed for the first time that integrins and the associated activation of nonreceptor tyrosine kinases promote growth and survival of cardiomyocytes for compensatory cardiac hypertrophy.
  • His recent work show how nonreceptor tyrosine kinases promote fibroblast proliferation & extracellular matrix deposition as part of pathological decompensatory hypertrophy.
  • Obtained several extramural research funding.
  • Generated several research tools.
  • Published over 50 elegant papers in the field of cardiac hypertrophy and failure.
  • Ad hoc reviewer for numerous Journals and grant study sections.
  • Member of several societies including International Society of Heart Research, The American Heart Association & The American Physiology Society.
  • Actively involved in Graduate School service and teaching
  • One of the top 10 teachers of the Graduate School – 2005
  • Served as guide for Ph.D. students (4-Ph.D & 2-MD/Ph.D)
  • Trained several postdoctoral fellows and summer students Participated in several Student Advisory Committees.
  • His students and postdocs hold prominent positions in biomedical research in various countries.

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Dr. Harinath Kasiganesan, Ph.D.

Former Research Assistant Professor
Medical University of South Carolina
Charleston, USA.

 

DR. KASIGANESAN WILL PLAY AS A COLLABORATING INVESTIGATOR IN ESTABLISHING THE RESEARCH CENTRE

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  • Graduated in physiology from University of Madras.
  • Served as a Scientist in DDRO, Delhi.
  • 2005 – Moved to MUSC as postdoctoral fellow.
  • More than 10 years experience in creating all models of Cardiac disease in various species including mice, rats & felines.
  • He has excellent experience in creating these models and evaluating them by echocardiogram.
  • Primary person running animal core facility for MUSC Cardiology Research Labs.
  • Highly talented in isolating primary cardomyocytes – cultured for various experiments including contractile function of cardiomyocytes.
  • He has successfully developed a method to isolate adult primary cardiomyocytes and fibroblasts for adult mouse heart for use in vitro assays.
  • Dr. Harinath is highly motivated to undertake Research work in India and has moved to Chennai, India in 2016.

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Dr. Santhosh Mani, Ph.D.,

Former Research Asst. Professor,
Medical University of South Carolina
Charleston, USA.

 

DR. MANI WILL ALSO PLAY AS A COLLABORATING INVESTIGATOR IN ESTABLISHING THE RESEARCH CENTRE

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  • Graduated in Biochemistry – University of Madras
  • Solid Research experience for 12 years at MUSC in USA
  • Played lead roles in several Projects.
  • Published many elegant Research papers in reputed Journals.
  • Solid Research experience in designing pertinent experiments in cellular signaling.
  • Special training in immunochemistry, confocal microscopy, advanced methods in biochemistry & molecular biology.
  • Dr. Santhosh Mani moved recently to Tamil Nadu, India, and he is highly motivated to undertake cardiac research work in India

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